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DynaMin inhibitory peptide, myristoylated (Cat No.: P000104), is a cell-permeable peptide inhibitor designed to block dynamin-dependent endocytosis. The myristoyl modification enhances membrane association and cellular uptake, enabling effective intracellular activity. By interfering with dynamin GTPase
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An inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis.
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Image Search Results
Journal: bioRxiv
Article Title: Differential isoform-specific control of KCC2 function in developing cortical neurons
doi: 10.64898/2026.01.25.701648
Figure Lengend Snippet: A , Timeline of the experiments. B , Representative confocal maximum projection images of dendritic sections of mature hippocampal neurons expressing scrambled (shNT) or KCC2a-specific (shKCC2a) shRNA, treated with a dynamin inhibitory peptide (DiP, 50 µM) 40 minutes before and during live Flag immunostaining. Scale: 5 µm. C , Summary boxplot showing the ratio of plasmalemmal (surf.) to the overall (total) KCC2b-Flag immunofluorescence intensity, normalized to control shNT condition. shNT control, n = 37; shNT +DiP, n = 39; shKCC2a control, n = 42; shKCC2a +DiP, n = 41 cells, from 4 independent cultures. Mann-Whitney rank-sum tests, p-value corrected for multiple comparisons using the Holm-Šídák method. *p < 0.05. D , Representative confocal maximum projection images of dendritic sections of hippocampal neurons expressing scrambled (shNT) or KCC2a-specific shRNA. Two hours before immunostaining with a panKCC2 antibody, neurons were treated with either a proteasome blocker (MG132, 2.5 µM), an inhibitor of the ubiquitin-activating enzyme (PYR-41, 50 µM), or untreated (control). Scale: 5 µm. E , Summary boxplot showing the intensity of endogenous KCC2 immunofluorescence in the different conditions, normalized to shNT control. shNT control, n = 44; shNT +MG132, n = 38; shNT +PYR41, n = 43; shKCC2a control, n = 43; shKCC2a +MG132, n = 40; shKCC2a +PYR41, n = 44 cells, from 4 independent cultures. Whitney rank-sum tests, p-value corrected for multiple comparisons using the Holm-Šídák method. **p < 0.01.
Article Snippet: Clathrin-mediated endocytosis was inhibited by incubating neurons for 40 min with the
Techniques: Expressing, shRNA, Immunostaining, Immunofluorescence, Control, MANN-WHITNEY, Ubiquitin Proteomics